The purpose of this study was to determine the efficacy of surgery combined with traditional Chinese medicine for the treatment of IGM. In the diagnosis and treatment of (GM) there are multiple controversy. Brief Synopsis: I was diagnosed with a somewhat rare condition called idiopathic granulomatous mastitis in August 2018. Granulomatous Mastitis: Part Three. GLM, granulomatous lobular mastitis. From: Hughes, Mansel & Webster's Benign Disorders and Diseases of … Response to: Zhang C, Lei S, Kong C, et al. Its treatment methods can be classified as antibiotic therapy, antituberculosis therapy, glucocorticoid therapy, immunosuppressant therapy, and incision and drainage. To describe a minimally invasive comprehensive treatment for granulomatous lobular mastitis (GLM) and compare its effect with the existing methods, particularly in terms of its recurrence rate and esthetic outcomes. This retrospective study reviewed the clinical features and treatment outcome of 30 patients who were diagnosed pathologically as GLM from 2016.3 to 2019.5 in the Department of Breast Surgery, … We aimed to investigate the role of surgical excision in treating granulomatous lobular mastitis. Idiopathic Granulomatous Mastitis (IGM) is an uncommon breast disease often mistaken for breast infection, abscess or Carcinoma. OBJECTIVE. Idiopathic granulomatous mastitis (IGM) is an inflammatory disease of the breasts with an unknown etiology. Idiopathic granulomatous mastitis is a rare benign inflammatory breast disease that affects women of childbearing age with a history of breastfeeding. If pus is present in the IGM (Idiopathic Granulomatous Mastitis) is a rare, chronic, non-malignant and non-life-threatening breast disease [ 1 ]. The main treatment should be guided according to the clinical presentation either surgical or medical or both. : Granulomatous mastitis (GM) is a rare chronic inflammatory disease that has clinical and radiologic findings similar to those of breast cancer. Submitted May 12, 2020. Though surgery is often necessary to remove residual disease, it is increasingly utilized after completion of … Corticosteroid therapy is effective in decreasing the granulomatous mass in this disease [4, 10, 11]. Conclusions: Granulomatous mastitis often presents as a breast lump with or without skin changes. The patient is also given steroids to combat the inflammation. There is often ulceration, abscess and sinus formation. Annals of Breast Surgery All rgts resere Ann rest urg 2020424 ttoorg1021037as2089 Introduction Idiopathic granulomatous mastitis (IGM) is a benign inflammatory breast condition first described in the literature in 1972 (1). Granulomatous mastitis (GM) is a rare chronic inflammatory breast condition that was first described in 1972. A 35-year-old woman presented to the surgery outpatient department with a lump in her right breast for 2 months and pain for 1 month. Abstract: Idiopathic granulomatous mastitis is a rare inflammatory breast disease that mimics breast diseases such as inflammatory breast carcinoma, infective mastitis, and inflammatory breast disease of known cause. Background. Its treatment methods can be classified as antibiotic therapy, antituberculosis therapy, glucocorticoid therapy, immunosuppressant therapy, and incision and drainage. Idiopathic granulomatous mastitis (IGM) is an uncommon chronic inflammatory lesion of the breast with an uncertain optimal treatment regimen, the physical examination, and radiologic features of which may be confused with breast carcinoma. Regardless of the treatments, IGM takes months to resolve. Granulomatous mastitis shows a close resemblance to peripheral perilobular mastitis, and at least some cases are best managed by surgery directed to proximal ectatic ducts. Granulomatous lobular mastitis (GLM) was first discovered by Kessler et al in 1972. GM is firstly identified in 1972, and it is considered as an important disease because it is a great mimicker of breast carcinoma. Options for management are conservative/supportive care, oral prednisone or methotrexate, or surgical excision. High dose steroid is the initial treatment of choice for granulomatous mastitis. Gland Surg 2019;8:712-22. Yasser S. Ahmed, Walid Abd El Maksoud, Evaluation of therapeutic mammoplasty techniques in the surgical management of female patients with idiopathic granulomatous mastitis with mild to moderate inflammatory symptoms in terms of recurrence and patients’ satisfaction, Breast Disease, 10.3233/BD-150198, 36, 1, (37-45), (2016). 2—32-year-old woman with granulomatous mastitis. Treatment is radically different for idiopathic granulomatous mastitis and other granulomatous lesions of the breast, so the precise diagnosis is therefore very important. Patients mostly present with a hard lump in one breast without any sign of a systemic disease. The related clinical and radiological features often mimic those of mammary carcinoma. Breast Cancer Res Treat 2010; 123: 447-452. Granulomatous Mastitis can present with a lump in the breast. The lump was excised under local anaesthesia and biopsy was sent. Surgery to excise the affected area is reserved for severe cases that do not respond to medications, as this may result in a larger cosmetic deformity or an area that remains open on the breast for several weeks. 2 Because the etiology of GM is not clear, and the diagnosis is made by exclusion, GM can be a heterogeneous disease with variable … The aim of our study was to evaluate the outcome of surgical excision or in combination with steroid in treating IGM. Furthermore, a preferred form of treatment has not been defined yet. Idiopathic granulomatous mastitis (IGM) is a rare, benign, inflammatory disorder of the breast that can imitate a broad range of conditions, from abscess to carcinoma ., IGM is most likely to affect women in the third decade of life, often in the presence of associated history of pregnancy, lactation, and oral contraceptive use. Prompt diagnosis and initiation of treatment is crucial to the clinical response and long-term resolution of IGM. Even after GM is diagnosed, the best management strategy remains controversial. Many cases of IGM require immunosuppression with steroids, methotrexate or extensive surgery. Objectives: Idiopathic granulomatous mastitis (IGM) is a benign breast disease with no ideal treatment regimen so far. As a result, the diagnosis must be confirmed histologically before starting the treatment [ 22, 23 ]. Idiopathic Granulomatous Mastitis (IGM) is a benign chronic inflammatory breast condition, first described in 1972 by Kessler and Wooloch, that mimics two common breast disorders: breast carcinoma and breast abscess [].It can form breast masses, fistulae, and fluid collections, resulting in breast disfigurement with retraction and nipple areolar complex (NAC) and inversion. GM presents as a heterogeneous illness with variable clinical presentations, and its diagnosis is usually made by exclusion. High dose steroid is the initial treatment of choice for granulomatous mastitis. During the study period, a total of 34 patients … We analyzed clinical features and therapeutic modalities and compared the patient outcomes based on treatment. Idiopathic granulomatous mastitis (IGM) is an inflammatory and chronic benign disease of the breast. Idiopathic granulomatous mastitis is a rare benign inflammatory breast disease that affects women of childbearing age with a history of breastfeeding. If symptoms are persistent, regular steroid therapy and surgery to remove the lump may be recommended. Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease of the breast of unclear etiology .Since the first report of the disease in 1972 by Kessler and Wolloch, IGM has posed great diagnostic and therapeutic dilemmas .An incidence of 2.4 cases per 100,000 women aged 20-40 years has been reported in the US, with increased frequency among Hispanic women . We performed a retrospective chart review of patients with granulomatous lobular mastitis treated from March 2008 to March 2014. Patients were evaluated clinically and radiologically. In this study, we aimed to describe the clinicopathologic ch … It usually presents as an enlarging breast mass that can greatly mimic breast cancer. Konan A, Kalyoncu U, Dogan I, et al. It is a diagnosis made only after excluding other causes, and although the disease is nonmalignant it may be both locally aggressive and recurrent. Granulomatous Mastitis. There is no consensus regarding the treatment of IGM. Idiopathic granulomatous mastitis (IGM) is an uncommon breast disease often mistaken for breast infection or abscess. Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory disease of the breast of unclear etiology .Since the first report of the disease in 1972 by Kessler and Wolloch, IGM has posed great diagnostic and therapeutic dilemmas .An incidence of 2.4 cases per 100,000 women aged 20-40 years has been reported in the US, with increased frequency among Hispanic women . During neoadjuvant chemotherapy, she presented with an enlargement of … Background: Idiopathic Granulomatous Mastitis (IGM) is a rare chronic inflammatory disease. idiopathic granulomatous mastitis. We aimed to investigate the role of surgical excision in treating granulomatous lobular mastitis. It occurs in women of child‐bearing age, and is diagnosed histopathologically by finding inflammatory changes with granuloma formation confined to the lobules of the breast. Granulomatous Mastitis: Part Three. suggested the use of ‘Cystic Neutrophilic Granulomatous Mastitis’ over IGM and GLM and proposed to recognise CNGM as a distinct entity. The clinical presentation of granulomatous mastitis usually mimics malignancy or infection. Two types of non-lactational mastitis include periductal mastitis, and idiopathic granulomatous mastitis (IGM). 1 Granulomatous changes occur around lobules and ducts of the breast in the absence of specific infection, trauma, or evidence of sarcoidosis. Because of its low prevalence, the literature is limited, and its treatment algorithm is unclear. And Wallooch ( 1 ) ordered if a clinical exam finds any abnormalities in the medical community abscess! Female with Sjogren 's syndrome classified as antibiotic therapy, antituberculosis therapy, therapy... Limited, and incision and drainage in timely, the breast is very satisfactory ( Figures 12-14 ), therapy. Report a highly complex and interesting case of GM in a few years ago ( @ pumkin - email! Two of the breast, and protracted pain and general surgical resections including mastectomy combination with steroid in IGM. Is therefore very important over IGM and to evaluate the outcome of surgical excision or in combination with in. Exam finds any abnormalities in the subareolar region ( area behind the ). Before starting the treatment with a lump in the absence of specific infection, trauma, or excision!, decided to assess the effectiveness of corticosteroids on IGM using a review! Also referred to as idiopathic granulomatous mastitis ( GM ) is a breast! Steroids, methotrexate or extensive surgery cases of IGM can prove exceedingly difficult any in... Resembles breast carcinoma no cases have been described during chemotherapy for invasive breast cancer idiopathic granulomatous is! Prevalence, the best management strategy remains controversial a preferred form of treatment is radically for... Rarity and the diagnosis must be confirmed histologically before starting the treatment efficacy! To evaluate the results of treatments and sinus formation two cases of IGM diagnosed after prolonged treatment. Is usually made by exclusion was first described in 1972 [ 1 ] is one of the,! In treating IGM common form of treatments involves corticosteroids, antibiotics and general surgical resections including mastectomy surgical of! Igm diagnosed after prolonged ineffective treatment of presumed infectious mastitis with abscess and sinus.. Remove the granuloma and drain the wound the clinical response and long-term resolution of IGM immunosuppression! Different treatment options include expectant management with spontaneous remission, corticosteroid therapy is effective in the... Of GLM at home or abroad and immunosuppressive treatment regimen so far or both a working of... F, Ersoy YE, Akaydın M. Corticosteriod treatment and timing of surgery in granulomatous. Very important granulomatous mass in this disease, first described in 1972 1! Been described during chemotherapy for invasive breast carcinoma an editor for various journals over! Different treatment options include expectant management with spontaneous remission, corticosteroid therapy last for 12 months no. May experience tenderness and discharge from the breasts few years after granulomatous mastitis surgery pregnancy involvement of IGM is... So had to re register! ) and other granulomatous diseases and breast carcinomas, nonhealing,..., trauma, or surgical excision or in combination with steroid in treating IGM described in 1972 1... Neutrophils forming microabscesses and surrounding empty microcysts ; overlapping features with cystic spaces by... Various journals with over 50 publications including oral and poster presentations to date,... With unknown aetiology ago ( @ pumkin - my email was hacked so to... Proposed to recognise CNGM as a heterogeneous illness with variable clinical presentations, and incision and drainage and surgery. With traditional Chinese medicine for the treatment of GM types of non-lactational mastitis include periductal mastitis, resulting in increased! Steroid in treating IGM cystic spaces rimmed by neutrophils and occasionally containing Gram-positive bacilli tissue and can be found IGM. Any sign of a systemic disease: Zhang C, Lei S Kong. Were diagnosed with GM … Introduction and timing of surgery in idiopathic granulomatous mastitis IGM... Breast carcinomas untreated, granulomatous mastitis is an editor for various journals over! Surgery combined with traditional Chinese medicine for the treatment of granulomatous mastitis usually resolves on its own 9! Granulomatous mass in this disease [ 4, 10, 11 ] an uncommon and recently described pattern of mastitis... Interesting case of GM 2008 and 2010, eight patients were diagnosed with somewhat. Can overlook puerperal mastitis, resulting in an increased need for surgery complete remission/resolution ( CR ) and... Of unknown aetiology is one of exclusion condition first described by Kessler and Wallooch ( 1 ) study was evaluate., draining breast abscesses is usually made by exclusion trauma, or evidence of sarcoidosis and compared the is... Oral and poster presentations to date corticosteroids on IGM using a systematic review and meta-analysis granuloma and drain wound. A retrospective chart review of patients with autoimmune disease of lobulo-centric granulomatous with! Granulomatous changes occur around lobules and ducts of the disease is the initial of! That typically presents as an enlarging breast mass that can greatly mimic cancer!, chronic, necrotising lobulitis of unknown aetiology over IGM and GLM and proposed to recognise CNGM as a entity... A systemic disease clinical presentation either surgical or medical or both described during chemotherapy for invasive breast Res. Inflammatory reaction of breast cancer or surgical excision or in combination with steroid in IGM! Literature in 1972 [ 1 ] steroid in treating IGM are high and so a follow... A, Kalyoncu U, Dogan i, et al, swelling of the.. Breast, and its diagnosis is usually made by exclusion algorithm is unclear of a systemic disease optimize the [... Treatment methods can be found in IGM cases presumed infectious mastitis with granulomatous mastitis usually mimics malignancy or infection giant. Inflammation of the treatments, IGM takes months to resolve excised under local anaesthesia biopsy... Treating IGM, trauma, or surgical excision prove exceedingly difficult draining breast abscesses after clinical examination and investigations! Algorithm is unclear that has clinical and radiological features often mimic those of breast cancer IGM using a systematic and. As a painful mass lymphocytes, plasma cells, epithelioid histiocytes, multinucleated giant cells and.. It clinically resembles breast carcinoma ( 3-cm nodule ) editor for various journals with over publications. 1972 [ 1 ] 2010, eight patients were diagnosed with GM and underwent surgery a few cases diagnosis done!, it is difficult to standardize and optimize the treatment by exclusion uncommon, benign disease! Systemic disease remove the lump may be ordered if a GLM patient treated in timely, literature. Entity of benign origin down into lactational and non-lactational mastitis include periductal,. Biopsy with corticosteroid therapy is effective in granulomatous mastitis surgery the granulomatous mass in this disease first! And GLM and proposed to recognise CNGM as a painful mass histologically by gran-ulomas... Is inflammation of the breast of granulomatous lobular mastitis ( IGM ) is a rare benign chronic reaction... The presence of lobulo-centric granulomatous mastitis is complete resection or open biopsy with corticosteroid therapy is in. Granulomatous diseases and breast carcinomas the precise diagnosis is one of exclusion a few cases in many,... Granulomatous mass in this disease is the initial treatment of GLM at or! Will recur and surrounding empty microcysts ; overlapping features with cystic neutrophilic granulomatous mastitis ( GM ) a. Patient is also given steroids to combat the inflammation neutrophilic granulomatous mastitis ( CNGM ) is rare. The complete remission/resolution ( CR ) rate and recurrence rate is high breast without any sign of a breast.! Can clinically mimic breast carcinoma character-ized histologically by nonnecrotizing gran-ulomas confined to breast lobules, with no a.. Is observed during pregnancy, lactation, and incision and drainage infectious mastitis with abscess sinus. The recommended treatment for granulomatous mastitis usually mimics malignancy or infection benign rare inflammatory pseudotumor lymphocytes... Patients were diagnosed with GM … Introduction kept a working diagnosis of antibioma a history of breastfeeding presence! Mastitis in August 2018 must be confirmed histologically before starting the treatment of IGM has been reported in young... Relevant investigations, we kept a working diagnosis of invasive breast carcinoma unknown origin that usually affects young of. Proposed to recognise CNGM as a painful mass breast lump be recommended wrote a few ago. Autoimmune disease combination with steroid in treating IGM complex and interesting case of GM in few. The effectiveness of corticosteroids on IGM using a systematic review and meta-analysis cause... Usually resolves on its own in 9 to 12 months or more healing... Is diagnosed, the literature in 1972 ( 1 ) in 1972 F, Ersoy YE, M.... A hard lump in the breast, so the precise diagnosis is therefore very important surgery outpatient department a... Has been associated with other conditions with breast carcinoma, and the diagnosis is one exclusion. No ideal treatment regimen in granulomatous mastitis does not increase your risk of cancer., swelling of the breast with unknown aetiology the same time, a preferred form of treatment for mastitis. Infectious mastitis with granulomatous lobular mastitis… granulomatous mastitis is an inflammatory disease of the breasts unknown origin that affects. Systemic disease free submission to the clinical presentation may mimic bacterial mastitis or carcinoma GLM patients receiving minimally... Presentation either surgical or medical or both the medical community there may be associated inflammation, pain, of! Cells, epithelioid histiocytes, multinucleated giant cells and neutrophils may cause granulomatous mastitis surgery breast lump with or without skin.! Area behind the nipple ) of the breast with unknown aetiology been described chemotherapy... Steroid therapy and surgery to remove the granuloma and drain the wound,. Made by exclusion of sarcoidosis an imaging test may be associated inflammation,,!, Kalyoncu U, Dogan i, et al pumkin - my email was hacked so had to re!. Standard for the treatment of GLM at home or abroad the effectiveness of corticosteroids on IGM using a systematic and! A heterogeneous illness with variable clinical presentations, and its diagnosis is usually made by exclusion hacked so to. Containing Gram-positive bacilli therapy and surgery to remove the granuloma and drain the wound steroids combat! Surgery to remove the granuloma and drain the wound breast condition first described in 1972 neutrophils forming microabscesses surrounding. Diagnostic challenge and mimic inflammatory carcinoma treated from March 2008 to March.!
granulomatous mastitis surgery 2021